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Article Dans Une Revue Experimental Cell Research Année : 1994

Differential sensitivity of FOS and JUN family members to calpains

S. Carillo
  • Fonction : Auteur
M. Pariat
  • Fonction : Auteur
A. M. Steff
  • Fonction : Auteur
M. Etienne-Julan
  • Fonction : Auteur

Résumé

Degradation of c-fos protein (c-FOS) in the cytoplasm is very rapid in vivo and constitutes a crucial regulation of the nuclear steady-state level through the control of the amount of full-length molecules available for nuclear transport. Using cytoplasmic extracts from various origins, we report herein that c-FOS degradation can be initiated in a calcium-dependent manner which involves cysteine proteases called milli- and micro-calpain. Interestingly, FOS-B, a member of the fos multigene family, as well as all members of the jun family (JUN-B, c-JUN and JUN-D) are also sensitive to calpains albeit to different extents. FRA-2, which is a c-FOS-related protein, is resistant to micro- but not to milli-calpain whereas FRA-1, another member of the fos family, is resistant to both proteases. Given the fact that a work by others (Hirai et al., 1991b) suggests that calpains can be involved in c-FOS and c-JUN degradation in vivo, our observations raises the possibility of a novel contribution to the regulation of AP-1 transcription complex activity through a differential control of the steady-state level of some of its components that involves calpains.
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Dates et versions

hal-02193241 , version 1 (24-07-2019)

Identifiants

  • HAL Id : hal-02193241 , version 1
  • PUBMED : 8183563

Citer

S. Carillo, M. Pariat, A. M. Steff, P. Roux, M. Etienne-Julan, et al.. Differential sensitivity of FOS and JUN family members to calpains. Experimental Cell Research, 1994, 9 (6), pp.1679--89. ⟨hal-02193241⟩
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