Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Microbes and Infection Année : 2006

Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages

Résumé

Lassa fever is a hemorrhagic fever caused by Lassa virus (LV), which primarily targets human dendritic cells (DC) and macrophages (MP). Massive numbers of viral particles are released with no effect on the viability, activation or maturation of these cells. LV does not inhibit the activation of cells induced by sCD40L or LPS. We report here the consequences of exogenous activation of LV-infected human DC and MP for viral replication. The activation of cells with lipopolysaccharide or exogenous poly(I-C) and the transfection of cells with poly(I-C) strongly inhibited LV replication, at least partly by inducing type I interferon (IFN) synthesis. In contrast, cell stimulation with sCD40L did not induce type I IFN responses or inhibit LV release. Recombinant type I IFNs strongly inhibited LV replication in both cell types, whereas IFNgamma and IFNlambda did not. The modest type I IFN production observed in LV-infected MP, but not in DC, was involved in controlling LV replication in MP. These results provide an explanation for the slower replication of LV in MP than in DC, and suggest that type I IFNs are crucial in the control of LV.

Domaines

Virologie

Dates et versions

hal-02291525 , version 1 (18-09-2019)

Identifiants

Citer

Sylvain Baize, Delphine Pannetier, Caroline Faure, Philippe Marianneau, Ingrid Marendat, et al.. Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages. Microbes and Infection, 2006, 8 (5), pp.1194-1202. ⟨10.1016/j.micinf.2006.02.002⟩. ⟨hal-02291525⟩
29 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More