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Article Dans Une Revue Cell Reports Année : 2019

Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex

Résumé

Changes in transcriptional regulation throughcis-regulatory elements are thought to drive brainevolution. However, how this impacts the identityof primate cortical neurons is still unresolved.Here, we show that primate-specificcis-regulatorysequences upstream of theDbx1gene promote hu-man-like expression in the mouse embryonic cere-bral cortex, and this imparts cell identity. Indeed,while Dbx1 is expressed in highly restricted corticalprogenitors in the mouse ventral pallium, it is main-tained in neurons in primates. Phenocopy of theprimate-like Dbx1 expression in mouse cortical pro-genitors induces ectopic Cajal-Retzius and subplate(SP) neurons, which are transient populations play-ing crucial roles in cortical development. A condi-tional expression solely in neurons uncouples mitoticand postmitotic activities of Dbx1 and exclusivelypromotes a SP-like fate. Our results highlight howtranscriptional changes of a single fate determinantin postmitotic cells may contribute to the expansionof neuronal diversity during cortical evolution

Domaines

Neurobiologie
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Dates et versions

hal-02322661 , version 1 (14-12-2020)

Identifiants

Citer

Yoko Arai, Andrzej Cwetsch, Eva Coppola, Sara Cipriani, Hidenori Nishihara, et al.. Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex. Cell Reports, 2019, 29 (3), pp.645-658.e5. ⟨10.1016/j.celrep.2019.09.007⟩. ⟨hal-02322661⟩
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