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Article Dans Une Revue Journal of Biological Chemistry Année : 2013

Interaction between the Elastin Peptide VGVAPG and Human Elastin Binding Protein

Nicolas Floquet
Stéphanie Baud

Résumé

Background: The interaction of the peptide VGVAPG with the elastin binding protein is critically involved in aneurysm progression. Results: A molecular model of this interaction is proposed and explored using a site-directed mutagenesis strategy. Conclusion: Three residues, Leu-103, Arg-107, and Glu-137, of elastin binding protein are critical players in this interaction. Significance: Our data now allow the design of antagonists of VGVAPG.
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Dates et versions

hal-02347668 , version 1 (05-11-2019)

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Charlotte Blanchevoye, Nicolas Floquet, Amandine Scandolera, Stéphanie Baud, Pascal Maurice, et al.. Interaction between the Elastin Peptide VGVAPG and Human Elastin Binding Protein. Journal of Biological Chemistry, 2013, 288 (2), pp.1317-1328. ⟨10.1074/jbc.M112.419929⟩. ⟨hal-02347668⟩
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