Isolation and Biological Characterization of Mouse LM Fibroblast Variants Resistant to the Cytotoxicity of Polyriboinosinic{middle dot}Polyribocytidylic Acid after Interferon Treatment - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of General Virology Année : 1984

Isolation and Biological Characterization of Mouse LM Fibroblast Variants Resistant to the Cytotoxicity of Polyriboinosinic{middle dot}Polyribocytidylic Acid after Interferon Treatment

T. Faure
  • Fonction : Auteur
P. Milhaud
  • Fonction : Auteur
H Fruteau de Laclos
  • Fonction : Auteur
G. Huez
  • Fonction : Auteur
H. de Laclos
  • Fonction : Auteur

Résumé

Mouse LM fibroblasts growing continuously in the absence of serum have an increased sensitivity to the cytotoxicity of poly(rI) X poly(rC) after interferon (IFN) exposure. This has allowed the isolation by an enrichment procedure of several independent and stable variant clones (IFN + I X C)R which are resistant to such a treatment. One of the resistant variants has been more extensively characterized as far as IFN action and IFN production are concerned. It behaves identically to the wild-type parent except for the spontaneous release of low amounts of IFN. The target of the mutation probably resides in a late step in the development of the cytotoxic response as revealed by microinjection techniques. The (IFN + I X C)R variants characterized here thus appear different from mutants in the IFN system isolated so far.

Dates et versions

hal-02361162 , version 1 (13-11-2019)

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Citer

T. Faure, P. Milhaud, H Fruteau de Laclos, Nadir Mechti, M. Silhol, et al.. Isolation and Biological Characterization of Mouse LM Fibroblast Variants Resistant to the Cytotoxicity of Polyriboinosinic{middle dot}Polyribocytidylic Acid after Interferon Treatment. Journal of General Virology, 1984, 65 (3), pp.617-627. ⟨10.1099/0022-1317-65-3-617⟩. ⟨hal-02361162⟩
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