Tonic, Phasic, and Integrator Components of Psychophysical Responses to Topical Capsaicin Account for Differences of Location and Sex - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue The Journal of Pain Année : 2005

Tonic, Phasic, and Integrator Components of Psychophysical Responses to Topical Capsaicin Account for Differences of Location and Sex

William Lariviere
  • Fonction : Auteur
Donald Mcburney
  • Fonction : Auteur
Maud Frot
Carey Balaban
  • Fonction : Auteur

Résumé

We reanalyze data of Frot et al on sex and location differences in the pain response to topical capsaicin using a dynamic model developed from responses to oral capsaicin. This model considers the pain response as the sum of 3 underlying component processes: a phasic component, a tonic component, and an integrator component. Sex differences in response to stimulation of both the cheek and ankle could be accounted for by a greater gain in the tonic mechanism. Responses to ankle stimulation showed a greater integrator component than responses to cheek stimulation, a negligible phasic component, and required a time delay. This analysis demonstrates that the model is applicable to responses to stimuli outside the oral cavity and that it can explain differences due to location and sex, in addition to explaining sensitization, desensitization, and individual differences in earlier studies. Application of this model in future genetic studies, for instance, would be more appropriate than the use of the peak response or the response at an arbitrarily determined time.

Dates et versions

hal-02472408 , version 1 (10-02-2020)

Identifiants

Citer

William Lariviere, Donald Mcburney, Maud Frot, Carey Balaban. Tonic, Phasic, and Integrator Components of Psychophysical Responses to Topical Capsaicin Account for Differences of Location and Sex. The Journal of Pain, 2005, 6 (12), pp.777-781. ⟨10.1016/j.jpain.2005.06.007⟩. ⟨hal-02472408⟩
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