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Article Dans Une Revue Nature Immunology Année : 2019

House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation

Nicolas Cenac

Résumé

Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance P. Intravital imaging and genetic approaches indicated that HDM-activated nociceptors drive the development of allergic skin inflammation by inducing the degranulation of mast cells contiguous to such nociceptors, through the release of substance P and the activation of the cationic molecule receptor MRGPRB2 on mast cells. These data indicate that, after exposure to HDM allergens, activation of TRPV1+Tac1+ nociceptor–MRGPRB2+ mast cell sensory clusters represents a key early event in the development of allergic skin reactions.

Dates et versions

hal-02627754 , version 1 (26-05-2020)

Identifiants

Citer

Nadine Serhan, Lilian Basso, Riccardo Sibilano, Camille Petitfils, James Meixiong, et al.. House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation. Nature Immunology, 2019, 20 (11), pp.1435-1443. ⟨10.1038/s41590-019-0493-z⟩. ⟨hal-02627754⟩
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