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Article Dans Une Revue Applied Physics Letters Année : 2020

Photoacoustic imaging through a cortical bone replica with anisotropic elasticity

Résumé

Photoacoustic (PA) imaging is an emerging modality which combines the high optical absorption contrast of biological chromophores with centimeter imaging depths and sub-millimeter resolution of ultrasonic (US) waves. However, PA imaging through cortical bone remains an unmet challenge. Cortical bone is an anisotropic medium which is not accurately modeled with existing PA image reconstruction methods. In this Letter, we address the PA source localization problem for imaging through a cortical bone-mimicking layer. Our approach accounts for both refraction and elastic anisotropy to accurately reconstruct an US and PA image in the presence of a cortical bone replica. We demonstrate our technique with a PA and US experiment, where we image a 700 µm diameter target beneath a cortical bone-mimicking plate. Pulse-echo US is used to estimate the wavespeed in each layer and create an anatomical image of the bone replica, and the PA source is reconstructed in reception-only using the wavespeed model defined with US. We compute the thickness of the plate with less than 1% error, whereas isotropic assumptions overestimate the thickness by 20% or more. Incorporating both refraction and anisotropy accurately localizes the target with PA and US at the true depth, whereas isotropic assumptions blur the lateral dimension and mislocate the target depth by 1.5-4 mm.
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Dates et versions

hal-02879602 , version 1 (24-06-2020)
hal-02879602 , version 2 (02-07-2020)

Identifiants

Citer

J Shepherd, Guillaume Renaud, P Clouzet, K. van Wijk. Photoacoustic imaging through a cortical bone replica with anisotropic elasticity. Applied Physics Letters, 2020, 116, ⟨10.1063/5.0011260⟩. ⟨hal-02879602v2⟩
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