Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey
Theodore Lytras
(1, 2)
,
Manolis Kogevinas
(2, 3, 4)
,
Hans Kromhout
(5)
,
Anne-Elie Carsin
(2, 1, 4)
,
Josep Maria Anto
(1, 2, 4)
,
Hayat Bentouhami
(6)
,
Joost Weyler
(7)
,
Joachim Heinrich
(8)
,
Dennis Nowak
(8)
,
Isabel Urrutia
(9)
,
Jesus Martínez-Moratalla
(10)
,
José Antonio Gullón
(11)
,
Antonio Pereira Vega
(12)
,
Chantal Raherison Semjen
(13)
,
Isabelle Pin
(14, 15)
,
Pascal Demoly
(16, 17)
,
Bénédicte Leynaert
(18)
,
Simona Villani
(19)
,
Thorarinn Gislason
(20)
,
Øistein Svanes
(21)
,
Mathias Holm
(22)
,
Bertil Forsberg
(23)
,
Dan Norback
(24)
,
Amar Mehta
(25)
,
Nicole M. Probst-Hensch
(26)
,
Geza Benke
(27)
,
Rain Jogi
(28)
,
Kjell Torén
(29)
,
Torben Sigsgaard
(30)
,
Vivi Schlünssen
(31, 30)
,
Mario Olivieri
(32)
,
Paul Blanc
(33)
,
John Watkins
(34)
,
Roberto Bono
(35)
,
A. Sonia Buist
(36)
,
Roel Vermeulen
(37)
,
Deborah Jarvis
(34, 35, 38)
,
Jan-Paul Zock
(2, 1, 4)
1
UPF -
Universitat Pompeu Fabra [Barcelona]
2 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
3 CRG-UPF - Center for Genomic Regulation
4 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
5 IRAS - Division of Occupational and Environmental Health, Institute for Risk Assessment
6 UA - University of Antwerp
7 Universiteit Antwerpen = University of Antwerpen [Antwerpen]
8 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
9 Galdakao Hospital
10 Complejo Hospitalario Universitario de Albacete
11 HUSA - Respiratory Department, Hospital Universitario San Agustín
12 Universidad de Huelva
13 BPH - Bordeaux population health
14 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
15 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
16 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
17 Sorbonne Université - Département de santé publique
18 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
19 UNIPV - Università degli Studi di Pavia = University of Pavia
20 Landspitali National University Hospital of Iceland
21 Haukeland University Hospital
22 GU - Göteborgs Universitet = University of Gothenburg
23 Umeå University
24 Uppsala University Hospital
25 Office of Research and Evaluation - Boston Public Health Commission
26 Swiss Tropical and Public Health Institute [Basel]
27 Monash University [Clayton]
28 University of Tartu
29 Sahlgrenska Academy at University of Gothenburg [Göteborg]
30 Aarhus University Hospital
31 Danish Ramazzini Centre - Department of Public Health [Copenhagen, Denmark]
32 UNIVR - Università degli studi di Verona = University of Verona
33 UC San Francisco - University of California [San Francisco]
34 Cardiff University
35 UNITO - Università degli studi di Torino = University of Turin
36 OHSU - Oregon Health and Science University [Portland]
37 University Medical Center [Utrecht]
38 Imperial College London
2 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
3 CRG-UPF - Center for Genomic Regulation
4 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
5 IRAS - Division of Occupational and Environmental Health, Institute for Risk Assessment
6 UA - University of Antwerp
7 Universiteit Antwerpen = University of Antwerpen [Antwerpen]
8 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
9 Galdakao Hospital
10 Complejo Hospitalario Universitario de Albacete
11 HUSA - Respiratory Department, Hospital Universitario San Agustín
12 Universidad de Huelva
13 BPH - Bordeaux population health
14 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
15 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
16 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
17 Sorbonne Université - Département de santé publique
18 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
19 UNIPV - Università degli Studi di Pavia = University of Pavia
20 Landspitali National University Hospital of Iceland
21 Haukeland University Hospital
22 GU - Göteborgs Universitet = University of Gothenburg
23 Umeå University
24 Uppsala University Hospital
25 Office of Research and Evaluation - Boston Public Health Commission
26 Swiss Tropical and Public Health Institute [Basel]
27 Monash University [Clayton]
28 University of Tartu
29 Sahlgrenska Academy at University of Gothenburg [Göteborg]
30 Aarhus University Hospital
31 Danish Ramazzini Centre - Department of Public Health [Copenhagen, Denmark]
32 UNIVR - Università degli studi di Verona = University of Verona
33 UC San Francisco - University of California [San Francisco]
34 Cardiff University
35 UNITO - Università degli studi di Torino = University of Turin
36 OHSU - Oregon Health and Science University [Portland]
37 University Medical Center [Utrecht]
38 Imperial College London
Theodore Lytras
- Fonction : Auteur
- PersonId : 785179
- ORCID : 0000-0002-4146-4122
Manolis Kogevinas
- Fonction : Auteur
- PersonId : 762958
- ORCID : 0000-0002-9605-0461
Anne-Elie Carsin
- Fonction : Auteur
- PersonId : 924703
Isabelle Pin
- Fonction : Auteur
- PersonId : 756749
- ORCID : 0000-0002-7529-6999
Pascal Demoly
- Fonction : Auteur
- PersonId : 754222
- IdHAL : pascal-demoly
- ORCID : 0000-0001-7827-7964
- IdRef : 03442959X
Bénédicte Leynaert
- Fonction : Auteur
- PersonId : 1064367
- IdHAL : benedicte-leynaert
- ORCID : 0000-0001-5045-2492
Kjell Torén
- Fonction : Auteur
- PersonId : 759883
- ORCID : 0000-0001-8509-7603
Résumé
Chronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey.Methods: Population samples aged 20-44 were randomly selected in 1991-1993, and followed up twice over 20 years. Participants without chronic cough or phlegm at baseline were analysed. Coded job histories during follow-up were linked to the ALOHA Job Exposure Matrix, generating occupational exposure estimates to 12 categories of chemical agents. Their association with CB incidence over both follow-ups was examined with Poisson models using generalised estimating equations.Results: 8794 participants fulfilled the inclusion criteria, contributing 13 185 observations. Only participants exposed to metals had a higher incidence of CB (relative risk (RR) 1.70, 95% CI 1.16 to 2.50) compared with non-exposed to metals. Mineral dust exposure increased the incidence of chronic phlegm (RR 1.72, 95% CI 1.43 to 2.06). Incidence of chronic phlegm was increased in men exposed to gases/fumes and to solvents and in women exposed to pesticides.Conclusions: Occupational exposures are associated with chronic phlegm and CB, and the evidence is strongest for metals and mineral dust exposure. The observed differences between men and women warrant further investigation.
Origine : Fichiers produits par l'(les) auteur(s)