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Article Dans Une Revue Platelets Année : 2020

Marginal band microtubules are acetylated by αTAT1

Anne-Sophie Ribba
  • Fonction : Auteur
Morgane Batzenschlager
Clotilde Rabat
  • Fonction : Auteur
Thierry Buchou
  • Fonction : Auteur
Sylvie Moog
  • Fonction : Auteur
Ekaterina Flin
  • Fonction : Auteur
Laurence Lafanechère
François Lanza
  • Fonction : Auteur
  • PersonId : 1080955
Karin Sadoul
  • Fonction : Auteur
  • PersonId : 1080956

Résumé

The discoid shape of resting platelets is maintained by a peripheral, circular bundle of microtubules called marginal band. Marginal band microtubules are acetylated on lysine 40 of the alpha-tubulin subunits. We have previously shown that the deacetylase HDAC6 is responsible for tubulin deacetylation in platelets and that the hyperacetylated state of the microtubules in HDAC6KO platelets correlates with faster activation/spreading kinetics, pointing to a regulatory role of this modification. So far, the question about the reverse enzyme, responsible for tubulin acetylation in platelets, has remained unanswered. Several enzymes have been described as having tubulin acetylation activity. Here we identify αTAT1 as the enzyme responsible for the acetylation of marginal band microtubules. We show that αTAT1 deficiency has only minor consequences for platelet production and function. A residual tubulin acetylation level in αTAT1 deficient platelet lysates suggests the presence of an additional tubulin-acetylating enzyme that is unable to acetylate marginal band microtubules.
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Dates et versions

hal-02990700 , version 1 (05-11-2020)

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Anne-Sophie Ribba, Morgane Batzenschlager, Clotilde Rabat, Thierry Buchou, Sylvie Moog, et al.. Marginal band microtubules are acetylated by αTAT1. Platelets, 2020, ⟨10.1080/09537104.2020.1759791⟩. ⟨hal-02990700⟩

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