Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 + T cell recovery can harbor replication-competent HIV despite viral suppression - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Science Translational Medicine Année : 2020

Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 + T cell recovery can harbor replication-competent HIV despite viral suppression

Alexis Sennepin
  • Fonction : Auteur
Aiwei Zhu
  • Fonction : Auteur
Gérémy Sannier
  • Fonction : Auteur
Jonathan Zheng
  • Fonction : Auteur
Lin Xu
  • Fonction : Auteur
Jean-Marc Massé
  • Fonction : Auteur
Michelle Cazabat
  • Fonction : Auteur
  • PersonId : 906606
Eliseo A Eugenin
  • Fonction : Auteur
  • PersonId : 1137790

Résumé

In addition to hemostasis, human platelets have several immune functions and interact with infectious pathogens including HIV in vitro. Here, we report that platelets from HIV-infected individuals on combined antiretroviral drug therapy (ART) with low blood CD4 + T cell counts (<350 cells/l) contained replication-competent HIV despite viral suppression. In vitro, human platelets harboring HIV propagated the virus to macrophages, a process that could be prevented with the biologic abciximab, an anti-integrin IIb/3 Fab. Furthermore, in our cohort, 88% of HIV-infected individuals on ART with viral suppression and with platelets containing HIV were poor immunological responders with CD4 + T cell counts remaining below <350 cells/l for more than one year. Our study suggests that platelets may be transient carriers of HIV and may provide an alternative pathway for HIV dissemination in HIV-infected individuals on ART with viral suppression and poor CD4 + T cell recovery.
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Dates et versions

hal-03000932 , version 1 (20-11-2020)

Identifiants

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Fernando Real, Claude Capron, Alexis Sennepin, Riccardo Arrigucci, Aiwei Zhu, et al.. Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 + T cell recovery can harbor replication-competent HIV despite viral suppression. Science Translational Medicine, 2020, 12, pp.eaat6263. ⟨10.1126/scitranslmed.aat626⟩. ⟨hal-03000932⟩
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