Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages
Résumé
Highlights d TB-induced anti-inflammatory M(IL-10) macrophages are prone to HIV-1 overproduction d Tunneling nanotubes between TB-induced M(IL-10) macrophages promote HIV-1 spread d The IL-10/STAT3 axis triggers tunneling nanotube induction in the TB microenvironment d M(IL-10) macrophages accumulate in TB/HIV co-infected patients and non-human primates
Domaines
Sciences du Vivant [q-bio]
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