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Journal Articles Acta Pharmaceutica Sinica B Year : 2020

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ-cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.

Marianna Porcino
  • Function : Author
Charlotte Martineau-Corcos
Weifeng Zhu
  • Function : Author
Gilles Patriarche
Christine Péchoux
Barbara Perronne
  • Function : Author
Alia Hassan
  • Function : Author
Rainer Kümmerle
  • Function : Author
Alexandre Michelet
  • Function : Author
Anne Zehnacker-Rentien
Kena Zhao
  • Function : Author
Tao Guo
  • Function : Author
Caifen Wang
  • Function : Author
Yong Zhou
  • Function : Author
Ting Xiong
  • Function : Author
Li Wu
  • Function : Author
  • PersonId : 762743
  • IdRef : 190923008
Xue Li
Priyanka Mittal
  • Function : Author
Senlin Shi
  • Function : Author
Ruxandra Gref
Jiwen Zhang

Dates and versions

hal-03095979 , version 1 (04-01-2021)



Marianna Porcino, Charlotte Martineau-Corcos, Weifeng Zhu, Gilles Patriarche, Christine Péchoux, et al.. Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery. Acta Pharmaceutica Sinica B, 2020, 10 (9), pp.1709-1718. ⟨10.1016/j.apsb.2020.04.015⟩. ⟨hal-03095979⟩
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