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Article Dans Une Revue Nature Neuroscience Année : 2021

Astrocytes mediate oxytocin's effect on central amygdala circuitry that regulates emotional behavior in rodents

Valery Grinevich
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Résumé

Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala (CeA), the release of OT modulates inhibitory circuits and thereby suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain-and loss-of-function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes express OT receptors and mediate anxiolytic and positive reinforcement effects of OT in the CeA of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlight astrocytes as essential components for modulation of emotional states under normal but also chronic pain conditions.
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Dates et versions

hal-03178553 , version 2 (23-03-2021)
hal-03178553 , version 1 (21-09-2021)

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Jérôme Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stéphanie Goyon, et al.. Astrocytes mediate oxytocin's effect on central amygdala circuitry that regulates emotional behavior in rodents. Nature Neuroscience, 2021, 24, pp.529-541. ⟨10.1038/s41593-021-00800-0⟩. ⟨hal-03178553v1⟩
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