Expression of mRNAs encoding BDNF and its receptor in adult rat hypothalamus - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue NeuroReport Année : 1998

Expression of mRNAs encoding BDNF and its receptor in adult rat hypothalamus

Florence Rage
  • Fonction : Auteur
Lucia Tapia-Arancibia
  • Fonction : Auteur
Sandor Arancibia
  • Fonction : Auteur

Résumé

We used a digoxigenin-UTP-labeled cRNA probe with in situ hybridization and Northern blot analysis to investigate the localization of brain derived neurotrophic factor (BDNF) mRNA and expression of its different transcripts in adult rat hypothalamus. As the BDNF gene is under the control of alternative multiple promoters, which provide tissue-specific gene expression, we studied whether these transcripts were expressed in adult hypothalamus. Our data revealed two novel sources of hypothalamic BDNF mRNA: the supraoptic and periventricular nuclei. In addition, we observed the expression of transcripts from exons, I, II and III as well as the presence of 1.6 and 4.2 kb BDNF mRNAs. Finally, our findings confirmed expression of mRNA encoding neurotrophins receptors in the hypothalamus.
Fichier non déposé

Dates et versions

hal-03412541 , version 1 (03-11-2021)

Identifiants

Citer

Frédéeric Marmigere, Florence Rage, Lucia Tapia-Arancibia, Sandor Arancibia. Expression of mRNAs encoding BDNF and its receptor in adult rat hypothalamus. NeuroReport, 1998, 9 (6), pp.1159-1163. ⟨10.1097/00001756-199804200-00037⟩. ⟨hal-03412541⟩

Collections

CNRS
9 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More