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Journal Articles Nature Neuroscience Year : 2021

Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin (1) , Elena Galea (2) , András Lakatos (3) , James O’callaghan (4) , Gabor Petzold (5) , Alberto Serrano-Pozo (6) , Christian Steinhäuser (7) , Andrea Volterra (8) , Giorgio Carmignoto (9) , Amit Agarwal (10) , Nicola Allen , Alfonso Araque , Luis Barbeito , Ari Barzilai , Dwight Bergles , Gilles Bonvento , Arthur Butt , Wei-Ting Chen , Martine Cohen-Salmon , Colm Cunningham , Benjamin Deneen , Bart de Strooper , Blanca Díaz-Castro , Cinthia Farina , Marc Freeman , Vittorio Gallo , James Goldman , Steven Goldman , Magdalena Götz , Antonia Gutiérrez , Philip Haydon , Dieter Heiland , Elly Hol , Matthew Holt , Masamitsu Iino , Ksenia Kastanenka , Helmut Kettenmann , Baljit Khakh , Schuichi Koizumi , C. Justin Lee , Shane Liddelow , Brian Macvicar , Pierre Magistretti , Albee Messing , Anusha Mishra , Anna Molofsky , Keith Murai , Christopher Norris , Seiji Okada , Stéphane Oliet , João Oliveira , Aude Panatier , Vladimir Parpura , Marcela Pekna , Milos Pekny , Luc Pellerin , Gertrudis Perea , Beatriz Pérez-Nievas , Pfrieger Fw (11) , Kira Poskanzer , Francisco Quintana , Richard Ransohoff , Miriam Riquelme-Perez , Stefanie Robel , Christine Rose , Jeffrey Rothstein , Nathalie Rouach , David Rowitch , Alexey Semyanov , Swetlana Sirko , Harald Sontheimer , Raymond Swanson , Javier Vitorica , Ina-Beate Wanner , Levi Wood , Jiaqian Wu , Binhai Zheng , Eduardo Zimmer , Robert Zorec , Michael Sofroniew , Alexei Verkhratsky
Carole Escartin
Molecular Imaging Research Center [Fontenay-aux-Roses]
Elena Galea
Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
András Lakatos
University of Cambridge [UK]
James O’callaghan
  • Function : Author
National Institute for Occupational Safety and Health [Morgantown, WV, USA]
Gabor Petzold
German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
Alberto Serrano-Pozo
Massachusetts General Hospital [Charlestown, MA, États-Unis]
Christian Steinhäuser
  • Function : Author
Universität Bonn = University of Bonn
Andrea Volterra
Université de Lausanne = University of Lausanne
Giorgio Carmignoto
  • Function : Author
Italian National Research Council [Padova, Italy]
Amit Agarwal
  • Function : Author
Universität Heidelberg [Heidelberg] = Heidelberg University
Nicola Allen
  • Function : Author
Alfonso Araque
Luis Barbeito
Ari Barzilai
  • Function : Author
Dwight Bergles
  • Function : Author
Gilles Bonvento
Arthur Butt
Wei-Ting Chen
  • Function : Author
Martine Cohen-Salmon
Colm Cunningham
  • Function : Author
Benjamin Deneen
Bart de Strooper
  • Function : Author
Blanca Díaz-Castro
  • Function : Author
Cinthia Farina
Marc Freeman
  • Function : Author
Vittorio Gallo
James Goldman
  • Function : Author
Steven Goldman
Magdalena Götz
Antonia Gutiérrez
Philip Haydon
Dieter Heiland
Elly Hol
Matthew Holt
Masamitsu Iino
  • Function : Author
Ksenia Kastanenka
  • Function : Author
Helmut Kettenmann
  • Function : Author
Baljit Khakh
  • Function : Author
Schuichi Koizumi
C. Justin Lee
  • Function : Author
Shane Liddelow
  • Function : Author
Brian Macvicar
Pierre Magistretti
  • Function : Author
Albee Messing
  • Function : Author
Anusha Mishra
Anna Molofsky
Keith Murai
  • Function : Author
Christopher Norris
  • Function : Author
Seiji Okada
Stéphane Oliet
  • Function : Author
João Oliveira
Aude Panatier
Vladimir Parpura
  • Function : Author
Marcela Pekna
Milos Pekny
  • Function : Author
Luc Pellerin
Gertrudis Perea
Beatriz Pérez-Nievas
  • Function : Author
Pfrieger Fw
Institut des Neurosciences Cellulaires et Intégratives
Kira Poskanzer
Francisco Quintana
  • Function : Author
Richard Ransohoff
  • Function : Author
Miriam Riquelme-Perez
  • Function : Author
Stefanie Robel
  • Function : Author
Christine Rose
Jeffrey Rothstein
Nathalie Rouach
David Rowitch
Alexey Semyanov
Swetlana Sirko
Harald Sontheimer
Raymond Swanson
Javier Vitorica
  • Function : Author
Ina-Beate Wanner
  • Function : Author
Levi Wood
  • Function : Author
Jiaqian Wu
  • Function : Author
Binhai Zheng
  • Function : Author
Eduardo Zimmer
  • Function : Author
Robert Zorec
Michael Sofroniew
Alexei Verkhratsky

Abstract

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters—preferably in vivo—plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.

Domains

Neurons and Cognition [q-bio.NC]
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Frank Pfrieger  : Connect in order to contact the contributor

https://hal.science/hal-03437017

Submitted on : Monday, December 13, 2021-5:21:07 PM

Last modification on : Tuesday, September 3, 2024-11:14:08 AM

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hal-03437017 , version 1 (13-12-2021)

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Carole Escartin, Elena Galea, András Lakatos, James O’callaghan, Gabor Petzold, et al.. Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩. ⟨hal-03437017⟩

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