Role of astrocyte senescence induced by Plasmodium in the pathogenesis of Cerebral Malaria
Résumé
Cerebral malaria (CM) is a fatal neurological syndrom due to Plasmodium (P.) falciparum infection, which kills 405,000 people annually(1). A central event involved in the pathogenesis of CM is the sequestration of infected red blood cells in the brain capillaries and the inflammatory response of activated glial cells (2). However, molecular mechanisms involved in the induction of the pro-inflammatory response of glial cells during CM remains unknown. In this study, we have examined if the senescence of glial cells induced by P. berghei ANKA infection participates in the neuroinflammatory response associated to CM.
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