Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2020

Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii

Anne-Sophie Godeux
  • Fonction : Auteur
Elin Svedholm
  • Fonction : Auteur
Agnese Lupo
Marisa Haenni
Xavier Charpentier

Résumé

With a great diversity in gene composition, including multiple putative antibiotic resistance genes, AbaR islands are potential contributors to multidrug resistance in Acinetobacter baumannii . However, the effective contribution of AbaR to antibiotic resistance and bacterial physiology remains elusive. To address this, we sought to accurately remove AbaR islands and restore the integrity of their insertion site. To this end, we devised a versatile scarless genome editing strategy.

Dates et versions

hal-03548950 , version 1 (31-01-2022)

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Anne-Sophie Godeux, Elin Svedholm, Agnese Lupo, Marisa Haenni, Samuel Venner, et al.. Scarless Removal of Large Resistance Island AbaR Results in Antibiotic Susceptibility and Increased Natural Transformability in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 2020, 64 (10), ⟨10.1128/AAC.00951-20⟩. ⟨hal-03548950⟩
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