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Journal Articles Evolution - International Journal of Organic Evolution Year : 2022

Sex‐related differences in aging rate are associated with sex chromosome system in amphibians

Hugo Cayuela
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  • PersonId : 765290
  • IdRef : 198603037
Jean‐paul Léna
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Victor Ronget
Iñigo Martínez‐solano
Erin Muths
David Pilliod
Benedikt Schmidt
Gregorio Sánchez‐montes
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Jorge Gutiérrez‐rodríguez
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Graham Pyke
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Kurt Grossenbacher
Omar Lenzi
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Jaime Bosch
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Karen Beard
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Lawrence Woolbright
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Brad Lambert
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David Green
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Nathalie Jreidini
Justin Garwood
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Robert Fisher
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Kathleen Matthews
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David Dudgeon
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Anthony Lau
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Jeroen Speybroeck
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Rebecca Homan
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Robert Jehle
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Eyup Başkale
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Emiliano Mori
Jan Arntzen
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Pierre Joly
Rochelle Stiles
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Michael Lannoo
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John Maerz
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Winsor Lowe
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Andrés Valenzuela‐sánchez
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Ditte Christiansen
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Claudio Angelini
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Jean‐marc Thirion
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Juha Merilä
Guarino Colli
Mariana Vasconcellos
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Taissa Boas
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Ísis da C. Arantes
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Pauline Levionnois
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Beth Reinke
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Cristina Vieira
Gabriel Marais
Jean‐michel Gaillard
David Miller
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Abstract

Sex-related differences in mortality are widespread in the animal kingdom. Although studies have shown that sex determination systems might drive lifespan evolution, sex chromosome influence on aging rates have not been investigated so far, likely due to an apparent lack of demographic data from clades including both XY (with heterogametic males) and ZW (heterogametic females) systems. Taking advantage of a unique collection of capture–recapture datasets in amphibians, a vertebrate group where XY and ZW systems have repeatedly evolved over the past 200 million years, we examined whether sex heterogamy can predict sex differences in aging rates and lifespans. We showed that the strength and direction of sex differences in aging rates (and not lifespan) differ between XY and ZW systems. Sex-specific variation in aging rates was moderate within each system, but aging rates tended to be consistently higher in the heterogametic sex. This led to small but detectable effects of sex chromosome system on sex differences in aging rates in our models. Although preliminary, our results suggest that exposed recessive deleterious mutations on the X/Z chromosome (the “unguarded X/Z effect”) or repeat-rich Y/W chromosome (the “toxic Y/W effect”) could accelerate aging in the heterogametic sex in some vertebrate clades.
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Dates and versions

hal-03644431 , version 1 (30-10-2022)

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Hugo Cayuela, Jean-François Lemaître Lemaître, Jean‐paul Léna, Victor Ronget, Iñigo Martínez‐solano, et al.. Sex‐related differences in aging rate are associated with sex chromosome system in amphibians. Evolution - International Journal of Organic Evolution, 2022, 76 (2), pp.346-356. ⟨10.1111/evo.14410⟩. ⟨hal-03644431⟩
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