Exploring the interactions between the human and viral genomes - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Human Genetics Année : 2020

Exploring the interactions between the human and viral genomes

Résumé

Over the last decade, genome-wide association studies led to major advances in identifying human genetic variants associated with infectious disease susceptibility. On the pathogen side, comparable methods are now applied to identify disease-modulating pathogen variants. As host and pathogen variants jointly determine disease outcomes, the most recent development has been to explore simultaneously host and pathogen genomes, through so-called genome-to-genome studies. In this review, we provide some background on the development of genome-to-genome analysis and we detail the first wave of studies in this emerging field, which focused on patients chronically infected with HIV and hepatitis C virus. We also discuss the need for novel statistical methods to better tackle the issues of population stratification and multiple testing. Finally, we speculate on future research areas where genome-to-genome analysis may prove to be particularly effective.
Fichier non déposé

Dates et versions

hal-03691733 , version 1 (09-06-2022)

Identifiants

Citer

Jacques Fellay, Vincent Pedergnana. Exploring the interactions between the human and viral genomes. Human Genetics, 2020, 139 (6-7), pp.777-781. ⟨10.1007/s00439-019-02089-3⟩. ⟨hal-03691733⟩
14 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More