WAO-ARIA consensus on chronic cough – Part 1: Role of TRP channels in neurogenic inflammation of cough neuronal pathways
Philip Rouadi
(1)
,
Samar A. Idriss
(1, 2)
,
Jean Bousquet
(3, 4, 5, 6)
,
Tanya M. Laidlaw
(7)
,
Cecilio R. Azar
(8, 9, 10)
,
Mona Sulaiman Al-Ahmad
(11)
,
Anahí Yáñez
(12)
,
Maryam Ali Y. Al-Nesf
(13)
,
Talal M. Nsouli
(14)
,
Sami L. Bahna
(15)
,
Eliane Abou-Jaoude
(14)
,
Fares H. Zaitoun
(16)
,
Usamah M. Hadi
(8)
,
Peter W. Hellings
(17, 18, 19, 20)
,
Glenis K. Scadding
(21)
,
Peter K. Smith
(22)
,
Mario Morais-Almeida
(23)
,
R. Maximiliano Gómez
(24)
,
Sandra N González Díaz
(25)
,
Ludger Klimek
(26)
,
Georges Juvelekian
(27)
,
Moussa A. Riachy
(28)
,
Giorgio Walter Canonica
(29)
,
David Peden
(30)
,
Gary W.K. Wong
(31)
,
James Sublett
(32)
,
Jonathan A. Bernstein
(33)
,
Lianglu Wang
(34)
,
Lk Tanno
(6, 35, 36)
,
Manana Chikhladze
(37)
,
Michael Levin
(38)
,
Yoon-Seok Chang
(39)
,
Bryan L. Martin
(40)
,
Luis Caraballo
(41)
,
Adnan Custovic
(42)
,
José Antonio Ortega-Martell
(43)
,
Erika Jensen-Jarolim
(44, 45)
,
Motohiro Ebisawa
(46)
,
Alessandro Fiocchi
(47)
,
Ignacio Javier Ansotegui
(48)
1
BESH -
Beirut Eye & ENT Specialist Hospital
2 Hôpital Edouard Herriot [CHU - HCL]
3 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
4 BIH - Berlin Institute of Health
5 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
6 UM - Université de Montpellier
7 Brigham and Women’s Hospital [Boston, MA]
8 AUB - American University of Beirut Faculty of Medicine and Medical Center
9 Middle East Institute of Health
10 CMC - Clemenceau Medical Center
11 Kuwait University
12 InAER - Investigaciones en Alergia y Enfermedades Respiratorias
13 Hamad Medical Corporation [Doha, Qatar]
14 ICI - International Cough Institute
15 LSU - Louisiana State University
16 LAU Medical Center-Rizk Hospital
17 VIB-KU Leuven Center for Microbiology [Leuven, Belgium]
18 University Hospitals Leuven [Leuven]
19 Ghent University Hospital
20 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
21 The Royal National TNE Hospital
22 Griffith University [Brisbane]
23 Hospital CUF Descobertas
24 Catholic University of Salta
25 UANL - Universidad Autonoma de Nuevo Leon [Mexique]
26 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
27 Saint George Hospital University Medical Center [UOB LIBAN]
28 HDF - Hôtel-Dieu de France
29 IRCCS Milan - Istituto Clinico Humanitas [Milan]
30 UNC - University of North Carolina [Chapel Hill]
31 CUHK - The Chinese University of Hong Kong [Hong Kong]
32 University of Louisville School of Medicine [Louisville]
33 University of Cincinnati College of Medicine
34 PUMCH - Peking Union Medical College Hospital [Beijing]
35 IDESP - Institut Desbrest de santé publique
36 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office
37 Akaki Tsereteli State University
38 University of Cape Town
39 Seoul National University Hospital
40 The Ohio State University Wexner Medical Center.
41 University of Cartagena
42 Imperial College London
43 UAEH - Universidad Autónoma del Estado de Hidalgo
44 Medizinische Universität Wien = Medical University of Vienna
45 Messerli Research Institute
46 Sagamihara National Hospital [Kanagawa, Japan]
47 IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital
48 Hospital Quirónsalud Bizkaia [Bilbao]
2 Hôpital Edouard Herriot [CHU - HCL]
3 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
4 BIH - Berlin Institute of Health
5 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
6 UM - Université de Montpellier
7 Brigham and Women’s Hospital [Boston, MA]
8 AUB - American University of Beirut Faculty of Medicine and Medical Center
9 Middle East Institute of Health
10 CMC - Clemenceau Medical Center
11 Kuwait University
12 InAER - Investigaciones en Alergia y Enfermedades Respiratorias
13 Hamad Medical Corporation [Doha, Qatar]
14 ICI - International Cough Institute
15 LSU - Louisiana State University
16 LAU Medical Center-Rizk Hospital
17 VIB-KU Leuven Center for Microbiology [Leuven, Belgium]
18 University Hospitals Leuven [Leuven]
19 Ghent University Hospital
20 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
21 The Royal National TNE Hospital
22 Griffith University [Brisbane]
23 Hospital CUF Descobertas
24 Catholic University of Salta
25 UANL - Universidad Autonoma de Nuevo Leon [Mexique]
26 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
27 Saint George Hospital University Medical Center [UOB LIBAN]
28 HDF - Hôtel-Dieu de France
29 IRCCS Milan - Istituto Clinico Humanitas [Milan]
30 UNC - University of North Carolina [Chapel Hill]
31 CUHK - The Chinese University of Hong Kong [Hong Kong]
32 University of Louisville School of Medicine [Louisville]
33 University of Cincinnati College of Medicine
34 PUMCH - Peking Union Medical College Hospital [Beijing]
35 IDESP - Institut Desbrest de santé publique
36 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office
37 Akaki Tsereteli State University
38 University of Cape Town
39 Seoul National University Hospital
40 The Ohio State University Wexner Medical Center.
41 University of Cartagena
42 Imperial College London
43 UAEH - Universidad Autónoma del Estado de Hidalgo
44 Medizinische Universität Wien = Medical University of Vienna
45 Messerli Research Institute
46 Sagamihara National Hospital [Kanagawa, Japan]
47 IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital
48 Hospital Quirónsalud Bizkaia [Bilbao]
Lk Tanno
- Fonction : Auteur
- PersonId : 987406
- IdHAL : luciana-kase-tanno
- ORCID : 0000-0003-3236-1225
- IdRef : 248787136
Michael Levin
- Fonction : Auteur
- PersonId : 775886
- ORCID : 0000-0003-2439-7981
Yoon-Seok Chang
- Fonction : Auteur
- PersonId : 791914
- ORCID : 0000-0003-3157-0447
Motohiro Ebisawa
- Fonction : Auteur
- PersonId : 798506
- ORCID : 0000-0003-4117-558X
- IdRef : 186089961
Alessandro Fiocchi
- Fonction : Auteur
- PersonId : 798507
- ORCID : 0000-0002-2549-0523
Résumé
Background: Cough features a complex peripheral and central neuronal network. The function of the chemosensitive and stretch (afferent) cough receptors is well described but partly understood. It is speculated that chronic cough reflects a neurogenic inflammation of the cough reflex, which becomes hypersensitive. This is mediated by neuromediators, cytokines, inflammatory cells, and a differential expression of neuronal (chemo/stretch) receptors, such as transient receptor potential (TRP) and purinergic P2X ion channels; yet the overall interaction of these mediators in neurogenic inflammation of cough pathways remains unclear. Objectives: The World Allergy Organization/Allergic Rhinitis and its Impact on Asthma (WAO/ ARIA) Joint Committee on Chronic Cough reviewed the current literature on neuroanatomy and pathophysiology of chronic cough. The role of TRP ion channels in pathogenic mechanisms of the hypersensitive cough reflex was also examined. Outcomes: Chemoreceptors are better studied in cough neuronal pathways compared to stretch receptors, likely due to their anatomical overabundance in the respiratory tract, but also their distinctive functional properties. Central pathways are important in suppressive mechanisms and behavioral/affective aspects of chronic cough. Current evidence strongly suggests neurogenic
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