Quantitative analysis of choriocapillaris alterations in swept-source optical coherence tomography-angiography during radiation retinopathy - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Retina Année : 2022

Quantitative analysis of choriocapillaris alterations in swept-source optical coherence tomography-angiography during radiation retinopathy

Christelle Gilli
  • Fonction : Auteur
Laurent Kodjikian
  • Fonction : Auteur
Olivier Loria
  • Fonction : Auteur
Laurence Rosier
  • Fonction : Auteur
Maxime Nhari
  • Fonction : Auteur
Anh Minh Nguyen
  • Fonction : Auteur
Joël Herault
  • Fonction : Auteur
Julia Salleron
  • Fonction : Auteur
Thibaud Mathis
  • Fonction : Auteur

Résumé

Purpose: To evaluate choriocapillaris alterations following proton beam therapy irradiation using swept-source optical coherence tomography-angiography, and to assess their correlation with the grade of radiation retinopathy (RR). Methods: Eyes with uveal melanoma evaluated before and after irradiation with proton beam therapy were included, as well as the healthy fellow eye. The gradation of RR was based on a previously published classification. Choriocapillaris flow voids area was analyzed using Phansalkar thresholding. Retinal vascularization was described by foveal avascular zone (FAZ) perimeter, FAZ area, FAZ circularity index, and percentage of nonperfusion area (PAN) in the superficial capillary plexus (SCP) or deep capillary plexus. Results: A total of 157 eyes of 83 patients were analyzed. Overall, there was a significant difference between the control group, the uveal melanoma before proton beam therapy group, and the grades of RR in the uveal melanoma after proton beam therapy group for FAZ perimeter (P < 0.001), FAZ area (P < 0.001), FAZ-circularity index (P < 0.001), PAN-SCP (P < 0.001), PAN-deep capillary plexus (P < 0.001), and choriocapillaris flow voids area (P < 0.001). Moreover, choriocapillaris flow voids area was significantly increased in the early stages of RR (P = 0.003) and was further significantly correlated with FAZ perimeter (P < 0.001), FAZ area (P < 0.001), FAZ-circularity index (P = 0.010), PAN-SCP (P < 0.001), and PAN-deep capillary plexus (P < 0.001). Conclusion: Quantitative optical coherence tomography-angiography alterations in the choriocapillaris microvascularization are an early biomarker of RR and are correlated to the severity of the disease.
Fichier non déposé

Dates et versions

hal-03790254 , version 1 (28-09-2022)

Identifiants

Citer

Christelle Gilli, Laurent Kodjikian, Olivier Loria, Charles Jabour, Laurence Rosier, et al.. Quantitative analysis of choriocapillaris alterations in swept-source optical coherence tomography-angiography during radiation retinopathy. Retina, 2022, 42 (10), pp.1995-2003. ⟨10.1097/iae.0000000000003559⟩. ⟨hal-03790254⟩
21 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More