CENP-A Regulation and Cancer - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Frontiers in Cell and Developmental Biology Année : 2022

CENP-A Regulation and Cancer

Charlène Renaud-Pageot
  • Fonction : Auteur
Jean-Pierre Quivy
  • Fonction : Auteur
Marina Lochhead
  • Fonction : Auteur

Résumé

In mammals, CENP-A, a histone H3 variant found in the centromeric chromatin, is critical for faithful chromosome segregation and genome integrity maintenance through cell divisions. Specifically, it has dual functions, enabling to define epigenetically the centromere position and providing the foundation for building up the kinetochore. Regulation of its dynamics of synthesis and deposition ensures to propagate proper centromeres on each chromosome across mitosis and meiosis. However, CENP-A overexpression is a feature identified in many cancers. Importantly, high levels of CENP-A lead to its mislocalization outside the centromere. Recent studies in mammals have begun to uncover how CENP-A overexpression can affect genome integrity, reprogram cell fate and impact 3D nuclear organization in cancer. Here, we summarize the mechanisms that orchestrate CENP-A regulation. Then we review how, beyond its centromeric function, CENP-A overexpression is linked to cancer state in mammalian cells, with a focus on the perturbations that ensue at the level of chromatin organization. Finally, we review the clinical interest for CENP-A in cancer treatment.
Fichier principal
Vignette du fichier
Renaud-pageot et al._CENP-A Regulation and Cancer_Front. cell Dev. Biol._2022.pdf (1.97 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03810723 , version 1 (11-10-2022)

Identifiants

Citer

Charlène Renaud-Pageot, Jean-Pierre Quivy, Marina Lochhead, Geneviève Almouzni. CENP-A Regulation and Cancer. Frontiers in Cell and Developmental Biology, 2022, 10, ⟨10.3389/fcell.2022.907120⟩. ⟨hal-03810723⟩
15 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More