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Article Dans Une Revue Cardiovascular Engineering and Technology Année : 2022

Particle Image Velocimetry to Evaluate Pulse Wave Velocity in Aorta Phantom with the lnD–U Method

Résumé

Purpose: Pulse Wave Velocity (PWV) is an indicator of arterial stiffness used in the prediction of cardiovascular disease such as atherosclerosis. Non-invasive methods performed with ultrasound probes allow one to compute PWV and aortic stiffness through the measurement of the aortic diameter (D) and blood flow velocity (U) with the lnD-U method. This technique based on in vivo acquisitions lacks validation since the aortic elasticity modulus cannot be verified with mechanical strength tests. Method: In the present study, an alternative validation is carried out on an aorta phantom hosted in an aortic flow simulator which mimics pulsatile inflow conditions. This in vitro setup included a Particle Image Velocimetry device to visualize flow in a 2D longitudinal section of the phantom, compute velocity fields (U), and track wall displacements in the aorta phantom to measure the apparent diameter (AD) variations throughout cycles. Results: The lnD-U method was then applied to evaluate PWV (5.92 ± 0.32 m/s) and calculate the Young's's modulus of the aorta phantom (0.66 ± 0.08 MPa). This last value was compared to the elasticity modulus (0.53 ± 0.07 MPa) evaluated with tensile strength tests on samples cut from the silicone phantom. Conclusion: Considering the uncertainties from the two methods, the measured elasticities are consistent and close to a 50-60 years old male aortic behavior. A comparison with in vivo data shows that the choice of silicone for the phantom material is a relevant and promising option to mimic the human aorta on in vitro systems.
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Dates et versions

hal-03842776 , version 1 (07-11-2022)

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Anaïs Moravia, Serge Simoëns, Mahmoud El Hajem, Benyebka Bousaïd, Marine Menut, et al.. Particle Image Velocimetry to Evaluate Pulse Wave Velocity in Aorta Phantom with the lnD–U Method. Cardiovascular Engineering and Technology, In press, ⟨10.1007/s13239-022-00642-2⟩. ⟨hal-03842776⟩
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