Protection of Glial Müller Cells by Dexamethasone in a Mouse Model of Surgically Induced Blood-Retinal Barrier Breakdown. - Archive ouverte HAL Access content directly
Journal Articles Investigative Ophthalmology & Visual Science Year : 2017

Protection of Glial Müller Cells by Dexamethasone in a Mouse Model of Surgically Induced Blood-Retinal Barrier Breakdown.

The 3D Retinal Capillary Circulation in Pigs Reveals a Predominant Serial Organization.

Abstract

Breakdown of the inner blood-retinal barrier (iBRB) occurs in many retinal disorders and may cause retinal edema often responsible for vision loss. Dexamethasone is used in clinical practice to restore iBRB. The aim of this study was to characterize the impact of a surgically induced iBRB breakdown on retinal homeostatic changes due to dystrophin Dp71, aquaporin-4 (AQP4), and Kir4.1 alterations in Müller glial cells (MGC) in a mouse model. The protective effect of dexamethasone was assessed in this model. Moreover, retinal explants were used to control MGC exposure to a hypoosmotic solution containing barium.
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Dates and versions

hal-03843817 , version 1 (08-11-2022)

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Lourdes Siqueiros-Marquez, Romain Bénard, Ophélie Vacca, Hugo Charles-Messance, Rodrigo Bolaños-Jimenez, et al.. Protection of Glial Müller Cells by Dexamethasone in a Mouse Model of Surgically Induced Blood-Retinal Barrier Breakdown.. Investigative Ophthalmology & Visual Science, 2017, 58 (2), pp.876-886. ⟨10.1167/iovs.16-20617⟩. ⟨hal-03843817⟩
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