Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma
Christian Mirian
,
Kathrine Grell
(1)
,
Tareq A Juratli
,
Felix Sahm
(2, 3, 4)
,
Sabine Spiegl‐kreinecker
,
Matthieu Peyre
,
Annamaria Biczok
,
Jörg‐christian Tonn
,
Stéphane Goutagny
(5, 6)
,
Luca Bertero
,
Andrea Daniela Maier
(7)
,
Lasse Rehné Jensen
,
Gabriele Schackert
,
Helle Broholm
,
David Scheie
(8)
,
Daniel P Cahill
,
Priscilla K Brastianos
(9, 10)
,
Jane Skjøth‐rasmussen
,
Kåre Fugleholm
,
Morten Ziebell
,
Tina Nørgaard Munch
,
Bjarne Winther Kristensen
,
Tiit Mathiesen
(11, 12)
1
Section of Biostatistics [Copenhagen]
2 KITZ - Hopp Children's Cancer Center Heidelberg [Heidelber, Germany]
3 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
4 Heidelberg University Hospital [Heidelberg]
5 Hôpital Beaujon [AP-HP]
6 OPTeN (UMR_S_1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie
7 VU - Vrije Universiteit Amsterdam [Amsterdam]
8 Rigshospitalet [Copenhagen]
9 Massachusetts General Hospital [Boston]
10 HMS - Harvard Medical School [Boston]
11 Institute of Environmental Medecine
12 UCPH - University of Copenhagen = Københavns Universitet
2 KITZ - Hopp Children's Cancer Center Heidelberg [Heidelber, Germany]
3 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
4 Heidelberg University Hospital [Heidelberg]
5 Hôpital Beaujon [AP-HP]
6 OPTeN (UMR_S_1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie
7 VU - Vrije Universiteit Amsterdam [Amsterdam]
8 Rigshospitalet [Copenhagen]
9 Massachusetts General Hospital [Boston]
10 HMS - Harvard Medical School [Boston]
11 Institute of Environmental Medecine
12 UCPH - University of Copenhagen = Københavns Universitet
Christian Mirian
- Function : Author
- PersonId : 1208199
- ORCID : 0000-0001-6801-0123
Kathrine Grell
- Function : Author
- PersonId : 1208200
- ORCID : 0000-0001-6398-6979
Tareq A Juratli
- Function : Author
- PersonId : 1208201
- ORCID : 0000-0003-2236-6719
Sabine Spiegl‐kreinecker
- Function : Author
Matthieu Peyre
- Function : Author
Annamaria Biczok
- Function : Author
Jörg‐christian Tonn
- Function : Author
Stéphane Goutagny
- Function : Author
- PersonId : 740516
- IdHAL : stephanegoutagny
- ORCID : 0000-0001-6975-9945
Luca Bertero
- Function : Author
- PersonId : 1208203
- ORCID : 0000-0001-9887-7668
Andrea Daniela Maier
- Function : Author
- PersonId : 1208204
- ORCID : 0000-0002-5930-0636
Lasse Rehné Jensen
- Function : Author
- PersonId : 1208205
- ORCID : 0000-0001-6931-4399
Gabriele Schackert
- Function : Author
Helle Broholm
- Function : Author
Daniel P Cahill
- Function : Author
Priscilla K Brastianos
- Function : Author
- PersonId : 1208206
- ORCID : 0000-0003-4470-8425
Jane Skjøth‐rasmussen
- Function : Author
Kåre Fugleholm
- Function : Author
Morten Ziebell
- Function : Author
Tina Nørgaard Munch
- Function : Author
- PersonId : 1208207
- ORCID : 0000-0001-5938-000X
Bjarne Winther Kristensen
- Function : Author
Abstract
TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.