Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Developmental and Comparative Immunology Année : 2007

Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor

Résumé

A novel antimicrobial peptide, named hedistin was identified from the coelomocytes of Nereis diversicolor. Hedistin shows no obvious similarities with other known peptides and constitutes the first antimicrobial peptide containing bromotryptophans demonstrated in annelids. cDNA and mass spectrometry analysis revealed that, upon bacteria challenge, this peptide is secreted following processing of a precursor containing a signal peptide and prosequences. Hedistin was shown to possess an activity against a large spectrum of bacteria including the methicillin resistant Staphylococcus aureus and Vibrio alginolyticus. The gene was demonstrated to be constitutively and exclusively expressed in circulating NK cells like known to play an important role in the immunity of the sand worm. These data contrast with those observed in another annelid, the leech, in which genes coding for antimicrobial peptides are upregulated in a specific tissue and peptides are rapidly released into the hemolymph after septic injury.
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Dates et versions

hal-03964325 , version 1 (31-01-2023)

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Aurélie Tasiemski, David Schikorski, Françoise Le Marrec-Croq, Christelle Pontoire-van Camp, Céline Boidin-Wichlacz, et al.. Hedistin: A novel antimicrobial peptide containing bromotryptophan constitutively expressed in the NK cells-like of the marine annelid, Nereis diversicolor. Developmental and Comparative Immunology, 2007, 31 (8), pp.749-762. ⟨10.1016/j.dci.2006.11.003⟩. ⟨hal-03964325⟩

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