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Article Dans Une Revue Cell Année : 1994

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

Richard Roy
  • Fonction : Auteur
Jörg P. Adamczewski
  • Fonction : Auteur
Thierry Seroz
  • Fonction : Auteur
Wim Vermeulen
  • Fonction : Auteur
Jean-Pierre Tassan
  • Fonction : Auteur
Laurent Schaeffer
  • Fonction : Auteur
Erich A. Nigg
  • Fonction : Auteur
Jan H. J. Hoeijmakers
  • Fonction : Auteur

Résumé

A protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.

Dates et versions

hal-03991564 , version 1 (15-02-2023)

Identifiants

Citer

Richard Roy, Jörg P. Adamczewski, Thierry Seroz, Wim Vermeulen, Jean-Pierre Tassan, et al.. The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell, 1994, 79 (6), pp.1093-1101. ⟨10.1016/0092-8674(94)90039-6⟩. ⟨hal-03991564⟩
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