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Journal Articles Nature Communications Year : 2023

Molecular versatility during pluripotency progression


Abstract A challenge during development is to ensure lineage segregation while preserving plasticity. Using pluripotency progression as a paradigm, we review how developmental transitions are coordinated by redeployments, rather than global resettings, of cellular components. We highlight how changes in response to extrinsic cues (FGF, WNT, Activin/Nodal, Netrin-1), context- and stoichiometry-dependent action of transcription factors (Oct4, Nanog) and reconfigurations of epigenetic regulators (enhancers, promoters, TrxG, PRC) may confer robustness to naïve to primed pluripotency transition. We propose the notion of Molecular Versatility to regroup mechanisms by which molecules are repurposed to exert different, sometimes opposite, functions in close stem cell configurations.

Dates and versions

hal-04010876 , version 1 (02-03-2023)



Giacomo Furlan, Aurélia Huyghe, Noémie Combémorel, Fabrice Lavial. Molecular versatility during pluripotency progression. Nature Communications, 2023, 14 (1), pp.68. ⟨10.1038/s41467-022-35775-4⟩. ⟨hal-04010876⟩
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