TERRA and Telomere Maintenance in the Yeast Saccharomyces cerevisiae - Archive ouverte HAL Access content directly
Journal Articles Genes Year : 2023

TERRA and Telomere Maintenance in the Yeast Saccharomyces cerevisiae


Telomeres are structures made of DNA, proteins and RNA found at the ends of eukaryotic linear chromosomes. These dynamic nucleoprotein structures protect chromosomal tips from endto-end fusions, degradation, activation of damage checkpoints and erroneous DNA repair events. Telomeres were thought to be transcriptionally silent regions because of their constitutive heterochromatin signature until telomeric long non-coding RNAs (LncRNAs) were discovered. One of them, TERRA (TElomeric Repeat-containing RNA), starts in the subtelomeric regions towards the chromosome ends from different telomeres and has been extensively studied in many evolutionarily distant eukaryotes. Changes in TERRA's expression can lead to telomeric dysfunction, interfere with the replicative machinery and impact telomere length. TERRA also co-localizes in vivo with telomerase, and can form RNA:DNA hybrid structures called R-loops, which have been implicated in the onset of senescence and the alternative lengthening of telomere (ALT) pathway. Yet, the molecular mechanisms involving TERRA, as well as its function, remain elusive. Here, we review the current knowledge of TERRA transcription, structure, expression, regulation and its multiple telomeric and extra-telomeric functions in the budding yeast Saccharomyces cerevisiae.
Fichier principal
Vignette du fichier
genes-14-00618-v2.pdf (1.67 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY - Attribution

Dates and versions

hal-04024137 , version 1 (10-03-2023)



Bechara Zeinoun, Maria Teresa Teixeira, Aurélia Barascu. TERRA and Telomere Maintenance in the Yeast Saccharomyces cerevisiae. Genes, 2023, 14 (3), pp.618. ⟨10.3390/genes14030618⟩. ⟨hal-04024137⟩
0 View
0 Download



Gmail Facebook Twitter LinkedIn More