Inclusion complex formation between sulfadiazine and various modified β-cyclodextrins and characterization of the complexes - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Drug Delivery Science and Technology Année : 2022

Inclusion complex formation between sulfadiazine and various modified β-cyclodextrins and characterization of the complexes

Résumé

β-Cyclodextrin (β-CD) and its derivatives are cyclic oligosaccharides which present the ability to form inclusion complexes with hydrophobic molecules and can bring new functionalities to a wide range of materials. As of today, the most used prophylactic drugs for wound dressing applications are sulfadiazine (SD) and its derivatives silver sulfadiazine (SSD). These drugs are used to prevent infections of the wounds; however, their low intrinsic water-solubility is a hindrance to their use. In this study, the inclusion complex formation between SD/SSD and the various β-CDs were assessed with various protocols. Isothermal Titration Calorimetry (ITC) experiments led to the conclusion that the formation constants measured for SD and SSD are sufficiently similar meaning that SD can be considered as a satisfactory model molecule. Phase Solubility Diagram (PSD) were built for SD and the various β-CDs, highlighting a 1:1 stoichiometry of inclusion and a linear increase in solubility of SD with increasing concentration of β-CDs- The formation constant ranged from 197 M−1 to 245 M−1 for the different β-CDs. X-Ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) experiments revealed the different physico-chemical properties affected by the formation of an inclusion complex. Finally, Nuclear Magnetic Resonance (NMR) experiments confirmed the depth of penetration of SD inside the β-CDs cavity as well as the orientation of SD, highlighting the fact that CM-β-CDs induce a deeper penetration than other β-CDs.

Dates et versions

hal-04098968 , version 1 (16-05-2023)

Identifiants

Citer

Bastien Michel, Ellinor Heggset, Kristin Syverud, Alain Dufresne, Julien Bras. Inclusion complex formation between sulfadiazine and various modified β-cyclodextrins and characterization of the complexes. Journal of Drug Delivery Science and Technology, 2022, 76, pp.103814. ⟨10.1016/j.jddst.2022.103814⟩. ⟨hal-04098968⟩

Collections

UGA CNRS LGP2 ANR
14 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More