Dual-Uptake Mode of the Antibiotic Phazolicin Prevents Resistance Acquisition by Gram-Negative Bacteria
Dmitrii Travin
(1, 2, 3)
,
Romain Jouan
(4)
,
Armelle Vigouroux
(4)
,
Satomi Inaba-Inoue
(5)
,
Joy Lachat
(4)
,
Fazal Haq
(4)
,
Tatiana Timchenko
(4)
,
Dmitry Sutormin
(1, 2, 3)
,
Svetlana Dubiley
(6, 3)
,
Konstantinos Beis
(5)
,
Solange Moréra
(4)
,
Konstantin Severinov
(7)
,
Peter Mergaert
(4)
1
Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia
2 Institute of Gene Biology
3 RAS - Russian Academy of Sciences [Moscow]
4 I2BC - Institut de Biologie Intégrative de la Cellule
5 Imperial College London
6 Skoltech - Skolkovo Institute of Science and Technology [Moscow]
7 Waksman Institute of Microbiology [Piscataway, NJ]
2 Institute of Gene Biology
3 RAS - Russian Academy of Sciences [Moscow]
4 I2BC - Institut de Biologie Intégrative de la Cellule
5 Imperial College London
6 Skoltech - Skolkovo Institute of Science and Technology [Moscow]
7 Waksman Institute of Microbiology [Piscataway, NJ]
Dmitrii Travin
- Fonction : Auteur
- PersonId : 808306
- ORCID : 0000-0003-0189-0159
Solange Moréra
- Fonction : Auteur
- PersonId : 738804
- IdHAL : solange-morera
- ORCID : 0000-0001-7781-0448
- IdRef : 083918892
Peter Mergaert
- Fonction : Auteur
- PersonId : 749107
- IdHAL : peter-mergaert
- ORCID : 0000-0002-5919-7317
- IdRef : 11092195X
Résumé
Many bacteria produce antimicrobial peptides to eliminate competitors and create an exclusive niche. These peptides act either by membrane disruption or by inhibiting essential intracellular processes.