Viruses in neurodegenerative diseases: More than just suspects in crimes - CNRS - Centre national de la recherche scientifique
Article Dans Une Revue (Article De Synthèse) PLoS Pathogens Année : 2022

Viruses in neurodegenerative diseases: More than just suspects in crimes

Pascal Leblanc
Ina Maja Vorberg

Résumé

Neurodegenerative diseases (NDs) such as Alzheimer’s and Parkinson’s disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiological factors that lead to neurodegeneration remain unknown but likely involve a combination of aging, genetic risk factors, and environmental stressors. Accumulating evidence hints at an association of viruses with neurodegenerative disorders and suggests that virus-induced neuroinflammation and perturbation of neuronal protein quality control can be involved in the early steps of disease development. In this review, we focus on emerging evidence for a correlation between NDs and viral infection and discuss how viral manipulations of cellular processes can affect the formation and dissemination of disease-associated protein aggregates.

Dates et versions

hal-04293368 , version 1 (18-11-2023)

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Citer

Pascal Leblanc, Ina Maja Vorberg. Viruses in neurodegenerative diseases: More than just suspects in crimes. PLoS Pathogens, 2022, 18 (8), pp.e1010670. ⟨10.1371/journal.ppat.1010670⟩. ⟨hal-04293368⟩
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