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Article Dans Une Revue Science Année : 2023

Yolk sac cell atlas reveals multiorgan functions during human early development

Issac Goh
Rachel Botting
Antony Rose
Simone Webb
Justin Engelbert
Yorick Gitton
Emily Stephenson
Mariana Quiroga Londoño
Michael Mather
  • Fonction : Auteur
Nicole Mende
Ivan Imaz-Rosshandler
Lu Yang
Dave Horsfall
Daniela Basurto-Lozada
Nana-Jane Chipampe
Victoria Rook
  • Fonction : Auteur
Jimmy Tsz Hang Lee
Mai-Linh Ton
Daniel Keitley
Pavel Mazin
M. Vijayabaskar
Rebecca Hannah
Laure Gambardella
Kile Green
Stephane Ballereau
  • Fonction : Auteur
Megumi Inoue
Elizabeth Tuck
Valentina Lorenzi
Kwasi Kwakwa
  • Fonction : Auteur
Clara Alsinet
Bayanne Olabi
  • Fonction : Auteur
Mohi Miah
Chloe Admane
  • Fonction : Auteur
Dorin-Mirel Popescu
  • Fonction : Auteur
Meghan Acres
  • Fonction : Auteur
David Dixon
Thomas Ness
Rowen Coulthard
  • Fonction : Auteur
Steven Lisgo
Deborah Henderson
Emma Dann
Chenqu Suo
Sarah Kinston
Jong-Eun Park
Krzysztof Polanski
John Marioni
Stijn van Dongen
  • Fonction : Auteur
Kerstin Meyer
Marella de Bruijn
  • Fonction : Auteur
James Palis
Sam Behjati
Elisa Laurenti
Nicola Wilson
Roser Vento-Tormo
Alain Chédotal
Omer Bayraktar
Irene Roberts
Laura Jardine
Berthold Göttgens
Sarah Teichmann
Muzlifah Haniffa

Résumé

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.

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Issac Goh, Rachel Botting, Antony Rose, Simone Webb, Justin Engelbert, et al.. Yolk sac cell atlas reveals multiorgan functions during human early development. Science, 2023, 381 (6659), ⟨10.1126/science.add7564⟩. ⟨hal-04302389⟩
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