Article Dans Une Revue Nature Plants Année : 2024

Comparisons of two receptor-MAPK pathways in a single cell-type reveal mechanisms of signalling specificity

Résumé

Cells harbour numerous receptor pathways to respond to diverse stimuli, yet often share common downstream signalling components. Mitogen-activated protein kinase (MPK) cascades are an example of such common hubs in eukaryotes. How such common hubs faithfully transduce distinct signals within the same cell-type is insufficiently understood, yet of fundamental importance for signal integration and processing in plants. We engineered a unique genetic background allowing direct comparisons of a developmental and an immunity pathway in one cell-type, the Arabidopsis root endodermis. We demonstrate that the two pathways maintain distinct functional and transcriptional outputs despite common MPK activity patterns. Nevertheless, activation of different MPK kinases and MPK classes led to distinct functional readouts, matching observed pathway-specific readouts. On the basis of our comprehensive analysis of core MPK signalling elements, we propose that combinatorial activation within the MPK cascade determines the differential regulation of an endodermal master transcription factor, MYB36, that drives pathway-specific gene activation.
Fichier principal
Vignette du fichier
s41477-024-01768-y.pdf (16.85 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04705751 , version 1 (23-09-2024)

Licence

Identifiants

Citer

Yan Ma, Isabelle Flückiger, Jade Nicolet, Jia Pang, Joe Dickinson, et al.. Comparisons of two receptor-MAPK pathways in a single cell-type reveal mechanisms of signalling specificity. Nature Plants, 2024, 10 (9), pp.1343-1362. ⟨10.1038/s41477-024-01768-y⟩. ⟨hal-04705751⟩
28 Consultations
10 Téléchargements

Altmetric

Partager

More