Article Dans Une Revue Physiology Année : 2024

Microtubule reorganization and quiescence: an intertwined relationship

Résumé

Quiescence is operationally defined as a reversible proliferation arrest. This cellular state is central for both organism development and homeostasis, its dysregulation causing many pathologies. The quiescent state encompasses very diverse cellular situations depending on the cell type and its environment. Further, quiescent cell properties evolve with time, a process that is thought to be at the origin of aging in multicellular organisms.

Microtubules are found in all eukaryotes, and are essential for cell proliferation as they support chromosome segregation and intracellular trafficking. Upon proliferation cessation and quiescence establishment, the microtubule cytoskeleton was shown to undergo significant remodeling. The purpose of this review is to examine the literature in search of evidence to determine whether the observed microtubule reorganizations are merely a consequence of quiescence establishment or if they somehow participate in this cell fate decision.

Mots clés

Fichier sous embargo
Fichier sous embargo
0 2 6
Année Mois Jours
Avant la publication
vendredi 18 avril 2025
Fichier sous embargo
vendredi 18 avril 2025
Connectez-vous pour demander l'accès au fichier

Dates et versions

hal-04743497 , version 1 (18-10-2024)

Identifiants

Citer

Isabelle Sagot, Damien Laporte. Microtubule reorganization and quiescence: an intertwined relationship. Physiology, 2024, ⟨10.1152/physiol.00036.2024⟩. ⟨hal-04743497⟩

Collections

CNRS ANR
17 Consultations
2 Téléchargements

Altmetric

Partager

More