Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils - UFR de Chimie de Sorbonne-Université Accéder directement au contenu
Article Dans Une Revue Journal of Physical Chemistry B Année : 2017

Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils

Résumé

Alzheimer’s disease is a challenge of the utmost importance for contemporary society. An early diagnosis is essential for the development of treatments and for establishing a network of support for the patient. In this light, the deposition in the brain of amyloid-β fibrillar aggregates, which is a distinctive feature of Alzheimer, is key for an early detection of this disease. In this work we propose an atomistic study of the interaction of amyloid tracers with recently published polymorphic models of amyloid-β 1–40 and 1–42 fibrils, highlighting the relationship between marker architectures and binding affinity. This work uncovers the importance of quaternary structure, and in particular of junctions between amyloid-β protofilaments, as the key areas for marker binding.

Domaines

Chimie

Dates et versions

hal-04039035 , version 1 (21-03-2023)

Identifiants

Citer

Francesca Peccati, Stefano Pantaleone, Vanessa Riffet, Xavier Solans-Monfort, Julia Contreras-García, et al.. Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils. Journal of Physical Chemistry B, 2017, 121 (38), pp.8926-8934. ⟨10.1021/acs.jpcb.7b06675⟩. ⟨hal-04039035⟩
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