Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery - CRCL-Signalisation, métabolisme et progression tumorale Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2024

Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery

Laurène Meyniel-Schicklin
Jérôme Amaudrut
Laetitia Lines
Farès Halitim
  • Function : Author
Jean-Laurent Paparin
  • Function : Author
Peter Machin
  • Function : Author
Raphaël Darteil
  • Function : Author
Diane Sampson
  • Function : Author
Eric C Meldrum
  • Function : Author
Benoit de Chassey

Abstract

Significance Viruses have designed small protein interfaces to interact with human proteins. These viral peptides are original molecules to modulate the activity of host targets and an inspiration to create original drugs. Here, the wealth of virus-host protein interactions existing in the literature is integrated in an substantial database. A sample peptide library is screened against several pathogens, highlighting peptides modulators of replication. From one of them, a drug discovery program identifies highly potent antiviral molecules interacting with human metabolic targets. These molecules are proven to be active for treatment of mouse model of nonalcoholic steatohepatitis with chronic kidney disease. Our approach validates an original biomimetic framework to address cellular functions for fundamental applications and drug discovery.
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Year Month Jours
Avant la publication
Thursday, January 23, 2025
Embargoed file
Thursday, January 23, 2025
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Dates and versions

hal-04411218 , version 1 (23-01-2024)

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Laurène Meyniel-Schicklin, Jérôme Amaudrut, Pierre Mallinjoud, Fabrice Guillier, Philippe E Mangeot, et al.. Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (5), pp.e2308776121. ⟨10.1073/pnas.2308776121⟩. ⟨hal-04411218⟩
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