Article Dans Une Revue Journal of medicinal plants research Année : 2019

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Résumé

Advanced glycation end-products (AGEs) have been shown to be implicated in many degenerative disorders as well as diabetic pathology. Of interest, several natural compounds including phenolic constituents are capable of inhibiting the formation of AGEs. Bio-guided fractionation of a methanol extract from Mangifera indica leaves led to the characterization of six antiglycative constituents including gallic acid (1), iriflophenone-3-C-β-D-glucoside (2), mangiferin (3), iriflophenone-3-C-(2'-Ogalloyl)-β-D-glucoside (4), hyperoside (5) and isoquercitrin (6). With IC 50 values lower than that of aminoguanidine, the six identified phenolic compounds can be regarded as remarkable inhibitors of advanced glycation end products formation and M. indica leaves should be considered as a potential nutraceutical resource to prevent carbonyl stress-related diseases.
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hal-04885343 , version 1 (14-01-2025)

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Fama Ndoye Samba, Fraisse Didier, Akendengué Blandine, Sylla Gueye Rokhaya, Sall Cheikh, et al.. Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.. Journal of medicinal plants research, 2019, 13, pp.129 - 134. ⟨10.5897/jmpr2019.6732⟩. ⟨hal-04885343⟩
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