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Article Dans Une Revue (Article De Synthèse) Advanced Drug Delivery Reviews Année : 2021

Elongated self-assembled nanocarriers: From molecular organization to therapeutic applications

Julie Mougin
Claudie Bourgaux
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Patrick Couvreur

Résumé

Self-assembled cylindrical aggregates made of amphiphilic molecules emerged almost 40 years ago. Due to their length up to micrometers, those particles display original physico-chemical properties such as important flexibility and, for concentrated samples, a high viscoelasticity making them suitable for a wide range of industrial applications. However, a quarter of century was needed to successfully take advantage of those improvements towards therapeutic purposes. Since then, a wide diversity of biocompatible materials such as polymers, lipids or peptides, have been developed to design self-assembling elongated drug nanocarriers, suitable for therapeutic or diagnostic applications. More recently, the investigation of the main forces driving the unidirectional growth of these nanodevices allowed a translation toward the formation of pure nanodrugs to avoid the use of unnecessary side materials and the possible toxicity concerns associated.
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Dates et versions

hal-04355517 , version 1 (21-05-2024)

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Julie Mougin, Claudie Bourgaux, Patrick Couvreur. Elongated self-assembled nanocarriers: From molecular organization to therapeutic applications. Advanced Drug Delivery Reviews, 2021, 172, pp.127-147. ⟨10.1016/j.addr.2021.02.018⟩. ⟨hal-04355517⟩
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