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Article Dans Une Revue Dalton Transactions Année : 2018

Acridine-decorated cyclometallated gold( iii ) complexes: synthesis and anti-tumour investigations

Résumé

(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques.
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Dates et versions

hal-01947053 , version 1 (06-12-2018)

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Morwen R. M. Williams, Benoit Bertrand, Julio Fernandez-Cestau, Zoë A. E. Waller, Maria A. O'Connell, et al.. Acridine-decorated cyclometallated gold( iii ) complexes: synthesis and anti-tumour investigations. Dalton Transactions, 2018, 47 (38), pp.13523-13534. ⟨10.1039/c8dt02507j⟩. ⟨hal-01947053⟩
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