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Article Dans Une Revue Nature Communications Année : 2015

Genome-wide association study identifies multiple susceptibility loci for glioma

Jayaram Vijayakrishnan
  • Fonction : Auteur
Minouk J. Schoemaker
  • Fonction : Auteur
Sarah J. Fleming
  • Fonction : Auteur
Stefan Herms
Anthony Swerdlow
  • Fonction : Auteur

Résumé

Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10−8), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10−11), 12q21.2 (rs12230172, P=7.53 × 10−11) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10−9). Our findings provide further insights into the genetic basis of the different glioma subtypes.

Dates et versions

hal-01316579 , version 1 (17-05-2016)

Identifiants

Citer

Ben Kinnersley, Marianne Labussière, Amy Holroyd, Anna-Luisa Di Stefano, Peter Broderick, et al.. Genome-wide association study identifies multiple susceptibility loci for glioma. Nature Communications, 2015, 6, pp.8559. ⟨10.1038/ncomms9559⟩. ⟨hal-01316579⟩
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