Palladium-Catalyzed C8-Fluoroalkylation and C8-Fluoroalkenylation of Naphthalenes by C-H Activation - Laboratoire de Chimie Moléculaire (LCM) Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2024

Palladium-Catalyzed C8-Fluoroalkylation and C8-Fluoroalkenylation of Naphthalenes by C-H Activation

Résumé

In this study, two novel C8‐functionalization methods of 1‐carbonylnaphthalenes were developed. Leveraging iodonium triflates as coupling partners, we disclose palladium‐catalyzed C8‐fluoroalkylation and C8‐fluoroalkenylation processes. These protocols exhibit broad applicability across diverse naphthalene derivatives, owing to carbonyl directing groups at the C1 position which can be retained for subsequent applications or selectively removed, enhancing the versatility of the developed methodologies.
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Dates et versions

hal-04586884 , version 1 (24-05-2024)

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Hugo Amistadi-Revol, Julie Tremblais, Nicolas Casaretto, Sébastien Prévost. Palladium-Catalyzed C8-Fluoroalkylation and C8-Fluoroalkenylation of Naphthalenes by C-H Activation. European Journal of Organic Chemistry, In press, ⟨10.1002/ejoc.202400194⟩. ⟨hal-04586884⟩
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