Production of magnetic multilamellar liposomes as highly T(2)-efficient MRI contrast agents. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Nanomedicine Année : 2011

Production of magnetic multilamellar liposomes as highly T(2)-efficient MRI contrast agents.

Résumé

Lipid-based multilamellar vesicles loaded with aminosilane-modified maghemite nanoparticles (a-MNPs), also called magnetonions (MO), were analyzed for their magnetic resonance imaging (MRI) contrast agent properties. They were shown to be better T(2)-MRI contrast agents than commercial contrast agents and other reported liposome-based contrast agents as shown by their higher value of relaxivity ratio (r(2)/r(1) = 17), although a lower magnetic field intensity was used (0.2 T). Their high efficiency was explained by the aggregation of a-MNPs in between multilamellar vesicles, bilayers induced by MO preparation, and evidenced by cryo-TEM imaging. Magnetonions are then a promising platform for diagnosis and therapy. FROM THE CLINICAL EDITOR: In this study, magnetonions (MO) are presented as a very potent T2 relaxation enhancing MRI contrast agents. Such agents may be used in cell labeling and molecular imaging applications.

Domaines

Matériaux

Dates et versions

hal-00565258 , version 1 (11-02-2011)

Identifiants

Citer

Marie-Edith Meyre, Gérard Raffard, Jean-Michel Franconi, Etienne Duguet, Olivier Lambert, et al.. Production of magnetic multilamellar liposomes as highly T(2)-efficient MRI contrast agents.. Nanomedicine, 2011, 7 (1), pp.18-21. ⟨10.1016/j.nano.2010.10.011⟩. ⟨hal-00565258⟩
37 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More