Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Marine drugs Année : 2011

Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp.

Arlette Longeon
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Brent R Copp
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Elodie Quévrain
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Mélanie Roué
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Betty Kientz
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Sylvain Petek
Cécile Debitus
Marie-Lise Bourguet-Kondracki
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Résumé

Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A₂ (PLA₂), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA₂ inhibition (IC₅₀ 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.

Domaines

Chimie organique

Dates et versions

hal-00684789 , version 1 (03-04-2012)

Identifiants

Citer

Arlette Longeon, Brent R Copp, Elodie Quévrain, Mélanie Roué, Betty Kientz, et al.. Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp.. Marine drugs, 2011, 9 (5), pp.879-88. ⟨10.3390/md9050879⟩. ⟨hal-00684789⟩
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