First total synthesis and stereochemical revision of laxaphycin B and its extension to lyngbyacyclamide A. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2013

First total synthesis and stereochemical revision of laxaphycin B and its extension to lyngbyacyclamide A.

France Boyaud
  • Fonction : Auteur
Zahia Mahiout
  • Fonction : Auteur
Christine Lenoir
  • Fonction : Auteur
Shoubin Tang
  • Fonction : Auteur
Anne Witczak
  • Fonction : Auteur
Isabelle Bonnard
Bernard Banaigs
  • Fonction : Auteur
Tao Ye
Nicolas Inguimbert

Résumé

The first total synthesis of laxaphycin B was accomplished through stepwise automated Solid Phase Peptide Synthesis (SPPS), leading to the structural revision of its stereochemistry especially with regard to the configuration of one of the two 3-hydroxyleucines of this cyclic dodecapeptide of marine origin. The analogous Lyngbyacyclamide A was obtained by an extension of this synthesis.

Domaines

Chimie organique

Dates et versions

hal-00910980 , version 1 (28-11-2013)

Identifiants

Citer

France Boyaud, Zahia Mahiout, Christine Lenoir, Shoubin Tang, Joanna Wdzieczak-Bakala, et al.. First total synthesis and stereochemical revision of laxaphycin B and its extension to lyngbyacyclamide A.. Organic Letters, 2013, 15 (15), pp.3898-901. ⟨10.1021/ol401645m⟩. ⟨hal-00910980⟩
36 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More