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Article Dans Une Revue Physical Review Letters Année : 2013

Mechanical control of cell flow in multicellular spheroids.

Résumé

Collective cell motion is observed in a wide range of biological processes. In tumors, physiological gradients of nutrients, growth factors, or even oxygen give rise to gradients of proliferation. We show using fluorescently labeled particles that these gradients drive a velocity field resulting in a cellular flow in multicellular spheroids. Under mechanical stress, the cellular flow is drastically reduced. We describe the results with a hydrodynamic model that considers only convection of the particles by the cellular flow.
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Dates et versions

hal-01138971 , version 1 (03-04-2015)

Identifiants

  • HAL Id : hal-01138971 , version 1
  • PUBMED : 23581378

Citer

Morgan Delarue, Fabien Montel, Ouriel Caen, Jens Elgeti, Jean-Michel Siaugue, et al.. Mechanical control of cell flow in multicellular spheroids.. Physical Review Letters, 2013, 110 (13), pp.138103. ⟨hal-01138971⟩
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