Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation
Résumé
Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to
their ability to increase energy deposition and subsequent direct damage to cells and DNA within their
local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical
yields. In this work we present, for the first time, an in silico investigation, based on the general purpose
Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a
spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for
incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy.