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Article Dans Une Revue Journal of the American Chemical Society Année : 2017

Terbium(III) Luminescent Complexes as Millisecond-Scale Viscosity Probes for Lifetime Imaging

Résumé

Fluorescent probes that are able to directly measure viscosity are attractive candidates for the study of intracellular environments. We report a new class of luminescent rotors, based on the sensitized emission of a terbium(III) complex. A 4-fold increase in both quantum yield and luminescence lifetime was observed in viscous media for the studied complexes, with a lifetime ranging from 0.23 to 0.89 ms over a broad range of viscosities (0.6–1200 cP). The presented approach, relying on the millisecond-scale luminescence lifetime of the lanthanide ions, was applied to fixed T24 cancer cells using temporal sampling lifetime imaging microscopy.
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Dates et versions

hal-01848473 , version 1 (24-07-2018)

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Anh Thy Bui, Alexei Grichine, Alain Duperray, Pierre Lidon, François Riobé, et al.. Terbium(III) Luminescent Complexes as Millisecond-Scale Viscosity Probes for Lifetime Imaging. Journal of the American Chemical Society, 2017, 139 (23), pp.7693 - 7696. ⟨10.1021/jacs.7b02951⟩. ⟨hal-01848473⟩
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