l-Arginine Metabolism Impairment in Sepsis and Diseases: Causes and Consequences - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Chapitre D'ouvrage Année : 2016

l-Arginine Metabolism Impairment in Sepsis and Diseases: Causes and Consequences

Résumé

Sepsis is recognized as a common cause for admission in ICUs. In general, sepsis and many diseases lead to alterations of the metabolism of amino acids (AA), among them arginine (Ventura et al. Amino Acids 39:1417–1426, 2010) more especially. Indeed, in humans, sepsis is characterized by a substantial decrease in arginine pools. This decrease of arginine concentration is usually due to a major increase of its consumption and a decrease of its endogenous production leading to the concept of “arginine deficiency” (Ventura et al. Amino Acids 39:1417–1426, 2010). Hence, in sepsis, it is generally admitted that endogenous synthesis (i.e., arginine is a non-essential amino acid) cannot meet the needs and arginine becomes a conditionally essential AA (Pribis et al. JPEN J Parenter Enteral Nutr 36:53–59, 2012). This may have important consequences. As a matter of fact, arginine is not only a component of proteins but also a molecule that can generate a number of active metabolites (Fig. 12.1): arginine may be the precursor of nitric oxide (NO, which is essential for the immune system), of ornithine (which is recognized as a polyamine precursor), or of agmatine (which is a major regulator of cell functions). Moreover, arginine is an important element in muscle energy: after reacting with glycine and methionine, it allows the formation of creatine. Finally, arginine acts as a secretagogue (such as insulin, glucagon, growth hormones, prolactin, and catecholamines) (Wu. Amino Acids 37:1–17, 2009). This could explain why the impairment of arginine homeostasis in sepsis and several diseases can contribute to pathophysiological alterations.
Fichier non déposé

Dates et versions

hal-01957630 , version 1 (17-12-2018)

Identifiants

Citer

Christophe Moinard, Charlotte Breuillard, Christine Charrueau. l-Arginine Metabolism Impairment in Sepsis and Diseases: Causes and Consequences. L-Arginine in Clinical Nutrition, Springer, Humana Press, Cham, pp.145-157, 2016, 978-3-319-26007-5. ⟨10.1007/978-3-319-26009-9_12⟩. ⟨hal-01957630⟩
23 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More